Controlled release formulations of octreotide

Details Controlled release formulations of octreotide Controlled release formulations of octreotide

A - Human Necessities

61

K

A61K 9/50 (2006.01)

Patent

CA 2601304

A formulation of octreotide or pharmaceutically acceptable salts thereof, which provides controlled release of a therapeutically effective amount of octreotide for a period of at least about two months. Methods of treating acromegaly, decreasing growth hormone, decreasing IGF-1, and treating conditions associated with carcinoid tumors and VIPomas by administering a controlled release formulation of octreotide are provided herein.

L'invention porte sur une préparation d'octréotide ou de ses sels pharmacocompatibles, permettant l'administration à libération lente d'une dose à efficacité thérapeutique d'octréotide sur une période d'au moins deux mois. L'invention porte également sur des méthodes de traitement de l'acromégalie, de la décroissance de l'hormone de croissance, de la décroissance de l'IGF-1, et d'états associés à des tumeurs carcinoïdes et des VIPomas (tumeurs sécrétant le peptide intestinal vasoactif) consistant à administrer une préparation d'octréotide à libération lente.

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