Controlled release gastroresistant pharmaceutical...

A - Human Necessities – 61 – K

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Details

A61K 31/575 (2006.01) A61J 3/00 (2006.01) A61J 3/06 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2065652

Controlled release pharmaceutical formulations for oral administration coated by an enterosoluble gastroresistant film, preferably selected from gastroresistant granulates, gastroresistant tablets, gastroresistant hard gelatine capsules containing powders or granulates or two or more tablets or oily suspensions, gastroresistant soft gelatine capsules containing oily. suspensions and hard gelatine capsules containing gastroresistant granulates or two or more gastroresistant tablets, containing therapeutically effective amounts of a mixture of bile acids and their salts with alkali metals or organic bases, process for their preparation and therapeutic use thereof in the treatment of biliary calculoses, biliary dyspepsias, biliary cirrhosis and chronic and cholestatic hepatopathies.

Divulgation de formulations pharmaceutiques à libération contrôlée à administrer par voie orale enrobées d'une pellicule gastro-résistante entéro-soluble, choisie de préférence entre des granulés, des comprimés ou des gélules gastro-résistants contenant des poudres ou des granulés ou au moins deux comprimés ou suspensions huileuses, des capsules molles gastro-résistantes contenant des suspensions huileuses et des gélules contenant des granulés gastro-résistants ou au moins deux comprimés gastro-résistants, contenant des quantités thérapeutiquement efficaces d'un mélange d'acides biliaires et de leurs sels et de métaux alcalins ou de bases organiques; du procédé de leur préparation et de leur utilisation thérapeutique pour traiter les calculs biliaires, la dyspepsie biliaire, la cirrhose biliaire et les hépatopathies chroniques et cholostatiques.

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