Controlled release hydrocodone formulations

Details Controlled release hydrocodone formulations Controlled release hydrocodone formulations

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/26 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2389235

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an anal- gesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/C max ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

L'invention concerne une forme posologique solide d'hydrocodone à libération lente administrée par voie orale. Cette forme posologique contient une quantité d'hydrocodone efficace du point de vue analgésique ou un sel d'hydrocodone pharmaceutiquement acceptable ainsi qu'une quantité suffisante d'une matière à libération lente afin de rendre la forme posologique appropriée à une administration biquotidienne à un patient humain, cette forme posologique présentant un ratio C12/Cmax compris entre 0,55 et 0,85 et fournissant un effet thérapeutique pendant au moins environ 12 heures.

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