Controlled release implants

Details Controlled release implants Controlled release implants

A - Human Necessities

61

K

A61K 9/30 (2006.01) A61K 9/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2141459

A pulse release implant comprising: an axial biodegradable core; a first concentric layer comprising dehydrated hydrogel containing an active ingredient; and an outer coating, said outer coating being removable by the environment in which the im- plant will reside after administration. A process of preparing a pulse release implant including the steps of: coating an axially disposed biodegradable core material with a hydrogel containing an active ingredient to form a concentric coating; separating the coating into discrete segments disposed along the core material; dehydrating the hydrogel; coating the discrete segments with an outer coating, said outer coating being removable by the environment in which the implant will reside after administration; and removing the exposed core material to obtain the pulse release implants.

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