Controlled release liquid delivery compositions with low...

Details Controlled release liquid delivery compositions with low... Controlled release liquid delivery compositions with low...

A - Human Necessities

61

K

167/166

A61K 9/00 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2348016

The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.

L'invention concerne une composition polymère à libération contrôlée, qui comprend un polymère ou copolymère de base, un solvant organique, un additif polymère à libération contrôlée et un agent biologiquement actif. L'additif polymère à libération contrôlée atténue la décharge initiale de l'agent biologiquement actif libéré par la composition polymère au moment où elle se solidifie pour former l'implant solide. L'additif est de préférence un copolymère séquencé poly(lactide-co-glycolide)/polyéthylène glycol.

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