Controlled release morphine preparation

Details Controlled release morphine preparation Controlled release morphine preparation

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2140254

The present invention concerns an oral morphine preparation having essentially complete bioavailability and, for the ma- jor part of the dissolution, an essentially zero order and essentially pH independent release of morphine for a period of at least 8 hours, preferably at least 12 hours, during which period less than 100 % is dissolved. In the preparation, the morphine, in the form of an easily soluble salt, is present in combination with a buffering agent in a preparation coated with a diffusion mem- brane.

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