Controlled release of actives in skin

Details Controlled release of actives in skin Controlled release of actives in skin

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 8/90 (2006.01) A61K 9/14 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2676841

Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is - C - R - C - or - C -; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2),, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

L'invention concerne des compositions topiques dans lesquelles les composés actifs destinés à une délivrance topique au travers du stratum corneum sont complexés avec des nanosphères d'un copolymère tribloc ayant une structure A-B-A dans laquelle chaque bloc terminal A est un polymère ou oligomère hydrosoluble, hydrophile et non toxique; et le bloc du milieu B hydrophobe est un polymère ou oligomère hydrophobe ayant les mêmes unités de répétition ou des unités de répétition différentes d'une structure selon la formule : (I) dans laquelle X représente - C - R - C - ou - C -; Z est compris entre 2 et environ 100 inclus; R1 représente CH=CH ou (CH2), n étant compris entre 0 et 18 inclus; R2 est choisi parmi l'hydrogène et les groupements linéaires et ramifiés alkyle, alcoxy, alkylaryle et alcoxyaryle contenant jusqu'à 18 atomes de carbone; et R est choisi parmi une liaison ou les groupements linéaires et ramifiés alkyle, alcoxy, alkylaryle et alcoxyaryle contenant jusqu'à 18 atomes de carbone.

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