A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/343 (2006.01) A61K 9/00 (2006.01) A61K 47/34 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61P 9/06 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2433861
Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti- arrhythmia drugs are incorporated into hydrogels that biodegrade and adhere to the tissues to which the anti-arrhythmic drugs are to be delivered. The hydrogels may be formed in vitro or in vivo. In a preferred embodiment, the drugs are effective to lengthen atrial effective refractory period. A particularly preferred drug is amiodarone.
L'invention concerne la mise au point de méthodes d'application simples et efficaces et de libération locale contrôlée de médicaments anti-arythmiques sélectionnés, à partir d'un hydrogel appliqué ou polymérisé sur des tissus ou des vaisseaux cardiaques, associé précisément à un pontage cardiaque ou une autre chirurgie cardiaque. Ces médicaments anti-arythmiques sont incorporés dans des hydrogels qui se dégradent par voie biologique et adhèrent aux tissus auxquels les médicaments anti-arythmiques doivent être administrés. Ces hydrogels peuvent être formés in vitro ou in vivo. Dans un mode préféré de réalisation, ces médicaments allongent efficacement la période réfractaire auriculaire efficace. Un médicament préféré particulier est l'amiodarone.
Burns James W.
Miller Robert J.
Philbrook Michael C.
Skinner Kevin C.
Bereskin & Parr
Focal Inc.
Genzyme Corporation
LandOfFree
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