Controlled release of metal cation-stabilized interferon

Details Controlled release of metal cation-stabilized interferon Controlled release of metal cation-stabilized interferon

C - Chemistry, Metallurgy

07

K

C07K 14/56 (2006.01) A61K 9/16 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2195994

This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation-stabilized interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

L'invention concerne une composition et son procédé de préparation pour la libération régulée d'interféron. Cette composition comprend un polymère biocompatible et des particules d'un interféron stabilisé par un cation métallique, ces particules étant en dispersion dans ce polymère biocompatible. Le procédé de production d'une telle composition servant à la libération régulée d'interféron, consiste à dissoudre un polymère dans un solvant pour polymère pour former une solution polymère, à disperser dans cette solution des particules d'un interféron stabilisé par un cation métallique, puis à rendre ce polymère solide pour former une matrice polymère contenant une dispersion de particules d'interféron.

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