Controlled release of miotic and mydriatic drugs in the...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/46 (2006.01) A61K 9/00 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/221 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/728 (2006.01) A61K 31/765 (2006.01) A61K 47/36 (2006.01) A61L 31/04 (2006.01) A61F 9/00 (2006.01)

Patent

CA 2216417

The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

La présente invention concerne des compositions qui maintiennent l'intégrité structurale de la chambre antérieure de l'oeil pendant les opérations de chirurgie ophtalmologique, protégeant ainsi les tissus qui forment et recouvrent le segment antérieur de lésions éventuelles, et fournissant en même temps de façon continue un agent myotique ou mydriatique. La présente invention apporte des compositions comprenant un polymère viscoélastique et dans lesquelles l'émission continue d'un agent myotique ou mydriatique est obtenue par l'intermédiaire d'interactions ioniques; elle apporte également des compositions dans lesquelles l'émission continue d'un agent myotique ou mydriatique est obtenue par l'intermédiaire de microcapsules ou de micelles de copolymères.

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