Controlled release of phenolic opioids

Details Controlled release of phenolic opioids Controlled release of phenolic opioids

C - Chemistry, Metallurgy

07

D

C07D 489/00 (2006.01) A61K 31/485 (2006.01) A61K 31/496 (2006.01) C07D 489/08 (2006.01)

Patent

CA 2653741

A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.

L'invention concerne un procédé visant à administrer à un patient un opioïde phénolique à libération régulée à l'aide d'un promédicament capable, lors de l'activation enzymatique, de libérer l'opioïde phénolique par cyclisation intramoléculaire entraînant la formation d'urée cyclique, de carbamate ou de thiocarbamate.

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