A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/402 (2006.01) A61K 9/20 (2006.01) A61P 9/06 (2006.01)
Patent
CA 2686396
The present invention provides methods of treating and preventing arrhythmia and other diseases or disorders, using ion channel modulating compounds, including vernakalant hydrochloride. The present invention further provides controlled release oral formulations and dosages of vernakalant hydrochloride, which are effective in preventing arrhythmia. Certain methods and formulations of the present invention are adapted for the treatment and prevention of arrhythmia and other disease or disorders in subjects identified as having altered drug metabolism due to polymorphism of the gene encoding cytochrome P450 2D6.
L'invention concerne des procédés de traitement et de prévention de l'arythmie et d'autres maladies ou troubles, en utilisant des composés de modulation de canal ionique, y compris le chlorhydrate de vernakalant. La présente invention fournit en outre des formulations de libération commandée et des dosages oraux de chlorhydrate de vernakalant, qui sont efficaces dans la prévention de l'arythmie. Certains procédés et formulations de la présente invention conviennent pour le traitement et la prévention de l'arythmie et de toute autre maladie ou troubles chez des sujets identifiés comme un métabolisme médicamenteux modifié en raison du polymorphisme du gène codant pour le cytochrome P450 2D6.
Beatch Gregory N.
Wheeler Jeffery Jerome
Cardiome Pharma Corp.
Mccarthy Tetrault Llp
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