Controlled release pharmaceutical composition

Details Controlled release pharmaceutical composition Controlled release pharmaceutical composition

A - Human Necessities

61

K

167/169

A61K 47/38 (2006.01) A61K 9/20 (2006.01)

Patent

CA 1304684

ABSTRACT A solid, controlled release pharmaceutical composition is provided withenhanced levels of control over drug release. The composition comprises an acid addition salt or a quaternary ammonium salt of an oreanic base drug complexed with an anionic surfactant and distributed in a matrix of a hydrophilic polymer. The complex formation between the drug which is preferably an acid addition salt of an organic amine, and the surfactant which is preferably a sulphosuccinate, distributed in the hydrophilic polymer matrix, which is preferably a water soluble hydroxyalkylcellulose ether, results in a composition with excellent controlled release characteristics.

514590

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