Controlled release pharmaceutical composition with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2755814

The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol. The coating layer comprises a polymeric portion consisting of a water-insoluble neutral vinyl polymer or vinyl copolymer and an amino methacrylate copolymer and an excipients portion consisting of a lubricant, an emulsifier, a plasticizer and optionally a cellulosic compound.

La présente invention concerne une composition pharmaceutique à libération contrôlée, comportant un noyau, comprenant un principe pharmaceutique actif, le noyau étant enrobé d'une couche procurant une résistance à l'éthanol qui a l'effet d'assurer une résistance à l'éthanol au profil de libération du principe pharmaceutique actif une résistance à l'éthanol. La couche d'enrobage comporte une partie polymérique constituée d'un polymère vinylique ou d'un copolymère vinyle insoluble dans l'eau et d'un copolymère de méthacrylate aminé et d'une partie d'excipients constituée d'un lubrifiant, d'un émulsifiant, d'un plastifiant et éventuellement d'un composé cellulosique.

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