Controlled release pharmaceutical compositions

Details Controlled release pharmaceutical compositions Controlled release pharmaceutical compositions

A - Human Necessities

61

K

167/164

A61K 9/32 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2081709

This invention relates to a controlled release pharmaceutical composition comprising: (a) an outer layer comprising a pH independent hydrophilic polymer together with one or more fillers; and (b) one or more inner layers each comprising an active ingredient; wherein the outer layer is gradually removed by a combination of dissolution and erosion following administration and the inner layer or layers is gradually removed by a combination of dissolution and erosion or disintegrates rapidly once exposed; and processes for the preparation thereof. In particular the invention relates to pharmaceutical compositions for the controlled release of H2- antagonists or serotonin agonists or antagonists.

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