Controlled release pharmaceutical compositions for the oral...

A - Human Necessities – 61 – K

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Details

A61K 31/455 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/4422 (2006.01)

Patent

CA 2216277

Controlled release pharmaceutical compositions for the oral administration of nifedipine comprising an amorphous coprecipitate of nifedipine and polyvinylpyrrolidone and suitable excipients, the release being modulable from 8 to 24 hours modifying the amount and the kind of used excipients. Said compositions show a high solubility and bioavailability in addition to the advantage of the controlled release.

Compositions pharmaceutiques à libération contrôlée pour l'administration par voie orale de nifédipine, composées d'un coprécipité amorphe de nifédipine et de polyvinylpyrrolidone et d'excipients appropriés. Elles peuvent être libérées sur un période de 8 à 24 heures selon la quantité et la sorte d'excipients utilisés. Elles sont très solubles et biodisponibles, en plus d'avoir l'avantage d'une libération contrôlée.

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