Controlled release pharmaceutical formulations of nitazoxanide

Details Controlled release pharmaceutical formulations of nitazoxanide Controlled release pharmaceutical formulations of nitazoxanide

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61K 9/24 (2006.01) A61K 9/52 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2752233

Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.

L'invention concerne des formulations posologiques solides de nitazoxanide ou d'un analogue de nitazoxanide qui comprennent une partie à libération contrôlée et une partie à libération immédiate. La composition pharmaceutique est généralement sous forme d'une forme posologique bicouche orale solide comprenant (a) une première couche comprenant une première quantité de nitazoxanide ou d'un de ses analogues dans une formulation à libération contrôlée, et (b) une deuxième couche comprenant une deuxième quantité de nitazoxanide ou d'un de ses analogues dans une formulation à libération immédiate. L'invention concerne également des procédés d'utilisation des formulations dans le traitement de l'hépatite C.

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