Controlled release pharmaceutical preparation with ace...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/56 (2006.01) A61K 31/401 (2006.01) A61K 31/472 (2006.01) A61K 38/05 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2295013

The invention relates to a pharmaceutical preparation containing or consisting of the following components: (i) an initial dose of active agent containing the active agent and optional auxiliary agents (ii) a first type of controlled release pellet in which the active agent and the optional auxiliary agents are coated, and (iii) a second type of controlled release pellet in which the active agent and optional auxiliary agents are also coated. The active agent is an ACE inhibitor and the weight ratio of the masses of the coatings in (ii) and (iii) is between 1:2 and 1:7.

L'invention concerne une préparation pharmaceutique à libération contrôlée contenant les constituants suivants ou constituée de ceux-ci: (i) une dose initiale de principe actif, contenant, outre des additifs facultatifs, le principe actif, (ii) un premier type de granulés à libération contrôlée, dans lequel le principe actif ainsi que les additifs facultatifs sont enrobés d'un revêtement, et (iii) une deuxième type de granulés à libération contrôlée, dans lequel le principe actif ainsi que les additifs facultatifs sont de nouveau enrobés d'un revêtement. Le principe actif est constitué par un inhibiteur de l'enzyme de conversion de l'angiotensine, et les masses des revêtements selon (ii) et (iii) se situent dans des rapports en poids compris entre 1: 2 et 1: 7.

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