Controlled release preparation containing a salt of morphine

Details Controlled release preparation containing a salt of morphine Controlled release preparation containing a salt of morphine

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/22 (2006.01) A61K 9/36 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 9/62 (2006.01)

Patent

CA 2135639

A new pharmaceutical preparation containing a number of coated particles comprising a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine over the main part of the dose interval when administered once daily, providing a significantly reduced plasma concentration fluctuation compared to known morphine preparations. Also disclosed is a method for the manufacture of such a preparation and the use of such preparations for the manufacture of an analgesic useful in the treatment of severe chronical pain.

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