Controlled release preparations comprising tramadol and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7048 (2006.01) A61K 9/16 (2006.01) A61K 9/24 (2006.01) A61K 31/137 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2506807

This invention relates to an oral pharmaceutical preparation, suitable for dosing every 24 hours, comprising a substrate, which substrate comprises a pharmaceutically effective amount of tramadol or a salt thereof and a pharmaceutically effective amount of topiramate and wherein said substrate may be coated with a controlled release coating; said preparation having a specific dissolution rate in vitro.

L'invention se rapporte à une préparation pharmaceutique orale permettant une posologie d'administration toutes les 24 heures et comportant un substrat qui contient une quantité pharmaceutiquement efficace de tramadol ou d'un sel de tramadol et une quantité pharmaceutiquement efficace de topiramate, ledit substrat pouvant être recouvert d'un revêtement à libération contrôlée et ladite préparation ayant une vitesse de dissolution spécifique in vitro.

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