Controlled release preparations having multi-layer structure

Details Controlled release preparations having multi-layer structure Controlled release preparations having multi-layer structure

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2333555

The present invention is directed to preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs. The preparations precisely control the release of the drugs. The preparations consist of an outer layer wherein a water- soluble drug is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and one or more inner layers wherein a water- soluble drug, differing in kind or concentration from the one contained in the outer layer, is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and in which the outer and inner layers are concentrically located in diametral direction of rod-like preparations and both or one of the ends in the axial direction are opened so as to directly come into contact with the environment.

La présente invention concerne des préparations permettant la libération séparée d'au moins deux médicaments à des vitesses appropriées en fonction de la maladie, ou permettant de réguler avec précision les comportements de libération d'au moins deux médicaments. Ces préparations comprennent une couche externe renfermant un médicament hydrosoluble dispersé dans un véhicule réalisé dans une matière polymère non biodégradable et hydrophobe, et une ou plusieurs couches internes renfermant un médicament hydrosoluble, différent par le type ou la concentration du médicament contenu dans la couche externe, dispersé dans un véhicule réalisé dans une matière polymère non biodégradable et hydrophobe, la couche externe et les couches internes étant disposées de façon concentrique dans la direction diamétrale de préparations de type bâtonnets et l'une des extrémités ou les deux extrémités dans la direction axiale étant ouverte(s) de manière qu'elle(s) est/sont en contact direct avec le milieu ambiant.

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