Controlled release ruminant medicinal composition

Details Controlled release ruminant medicinal composition Controlled release ruminant medicinal composition

A - Human Necessities

61

K

167/164

A61K 9/26 (2006.01)

Patent

CA 1073357

CONTROLLED RELEASE RUMINANT MEDICINAL COMPOSITION Abstract A slow release oral dosage medicinal composition for ruminant animals which is a compressed dosage form of a dry, essentially water-insoluble, slowly digestible matrix is prepared by first treating an admixture of originally essentially undenatured native milk solids and the drug with a sufficient quantity of an aldehydic agent to insolubilize the milk protein solids This treated composition is then preferably granulated and the granules compressed under sufficient pressure to form a densified body which is not only resistant to disintegration for over twenty-four hours when tumbled in water, but also has a specific gravity at least greater than about 1 to cause the dosage form upon administration to a ruminant animal to have a tendency to sink in the rumino-recticular fluids and become entrapped in the rumino-recticular compartments.

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