A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/19 (2006.01) A61K 31/496 (2006.01) A61K 47/26 (2006.01) A61K 47/38 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2543242
A controlled release sterile freeze-dried aripiprazole formulation is provided which is formed of aripiprazole of a desired mean particle size and a vehicle therefor, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks. A method for preparing the controlled release freeze-dried aripiprazole formulation, and a method for treating schizophrenia employing the above formulation are also provided.
L'invention concerne une formulation d'aripiprazole lyophilisée stérile à libération contrôlée, qui comprend un composé d'aripiprazole présentant une taille moyenne de particules voulue et un excipient, et qui, après reconstitution avec de l'eau et injection intramusculaire, libère l'aripiprazole sur une période d'au moins une semaine environ et pouvant atteindre huit semaines. L'invention a trait à un procédé de préparation de la formulation d'aripiprazole lyophilisée à libération contrôlée, et à une méthode de traitement de la schizophrénie utilisant cette formulation.
Kostanski Janusz W.
Matsuda Takakuni
Naringrekar Vijay H.
Nerurkar Manoj
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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