Controlled release sulfonylurea formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/24 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)

Patent

CA 2441064

Disclosed in a controlled release sulfonylurea formulation. In certain embodiments, the invention comprises: (a) a core comprising: (i) a sulfonylurea or a pharmaceutically acceptable salt thereof; (ii) a pharmaceutically acceptable polymer; (b) a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid, wherein said dosage form provides a mean time to maximum plasma concentration (Tmax) of said sulfonylurea.

L'invention concerne une préparation de sulfonylurée à libération contrôlée. Dans certaines formes de réalisation, l'invention comprend: a) un noyau contenant i) une sulfonylurée ou un sel pharmaceutiquement acceptable de sulfonylurée, ii) un polymère pharmaceutiquement acceptable; b) une membrane entourant le noyau et perméable à la sulfonylurée et aux liquides gastrointestinaux. Cette forme posologique établit une durée moyenne relativement à la teneur maximale en plasma (T¿max?) de la sulfonylurée.

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