Controlled release systems for polymers

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2433361

The present invention relates to controlled release delivery of biologically active molecules from a solid composition prepared by exposure of the molecules to an organic compound. For instance, the organic compound is an organic solvent, such as an alcohol (e.g., preferably a lower alocohol, such as methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol, t- butanol, etc.), a mixture of alcohols, an aldehyde, a ketone, a hydrocarbon (saturated or unsaturated), or an aromatic hydrocarbon. The solvent can be a mixture of different organic solvents, or the resulting formulation can be a mixture of, e.g., different lyophilized preparations, such as may be used to control the release profile of the resulting admixture.

La présente invention concerne l'administration à libération régulée de molécules bioactives à partir d'une composition solide préparée par mise en contact de ces molécules avec un composé organique. Par exemple, ce composé organique peut se présenter sous la forme d'un solvant organique, tel qu'un alcool (de préférence un alcool inférieur tel que le méthanol, l'éthanol, l'isopropanol, le n-propanol, le n-butanol, l'isobutanol, le t-butanol, etc.), un mélange d'alcools, un aldéhyde, une cétone, un hydrocarbure (saturé ou insaturé) ou un hydrocarbure aromatique. Ledit solvant peut être un mélange de différents solvants organiques. La formulation résultante, quant à elle, peut être un mélange de préparations lyophilisées du type utilisé dans certains cas pour réguler le profil de libération du mélange résultant.

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