Controlled release tablet

Details Controlled release tablet Controlled release tablet

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 31/455 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2258709

A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60 % of a water swellable polymer and a lubricant. The water swellable polymer is chosen such that the swelling rate of the polymer is equal to the dissolution rate of the swollen polymer. The excipient may also include such other ingredients as diluents, fillers, binders, solubilizers, emulsifiers, and other pharmacologically inactive compounds. The polymer is chosen with the pharmaceutical agent in mind such that the tablet will be fully dissolved at the same time that the last of the pharmaceutical agent is released.

L'invention concerne un comprimé à libération contrôlée contenant un agent pharmaceutique et un excipient. L'excipient comprend au moins 60 % environ d'un polymère qui gonfle dans l'eau et d'un lubrifiant. Le polymère qui gonfle dans l'eau est choisi pour que la vitesse de gonflement du polymère soit égale à la vitesse de dissolution du polymère gonflé. L'excipient peut également comprendre d'autres ingrédients tels que des diluants, des charges, des liants, des agents de solubilisation, des émulsifiants et d'autres composés inactifs sur le plan pharmacologique. On choisit le polymère en tenant compte de l'agent pharmaceutique, pour que le comprimé soit complètement dissous à peu près au moment où les dernières traces de l'agent pharmaceutique sont libérées.

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