Controlled release vehicle

Details Controlled release vehicle Controlled release vehicle

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/47 (2006.01) A61K 47/38 (2006.01) C12N 11/04 (2006.01) A61F 13/15 (2006.01)

Patent

CA 2082496

ABSTRACT OF THE DISCLOSURE A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g., carboxymethylcellulose, which is treated with a cross-linking agent such as aluminum ions and, preferably, hydrophobicity agent such as acetic acid. The vehicle is broken down by a release agent, e.g., cellulase, which may be coated on the vehicle together with a coating agent, e.g., hydroxypropylcellulose. The vehicle is dried, entrapping the molecule to be entrapped, e.g., an enzyme, and hydration activates the cellulase which breaks down the carboxymethylcellulose, releasing the entrapped molecule.

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