Controlled released acth containing microspheres

Details Controlled released acth containing microspheres Controlled released acth containing microspheres

A - Human Necessities

61

K

A61K 38/35 (2006.01) A61K 9/16 (2006.01) A61K 9/70 (2006.01) A61K 38/21 (2006.01) A61K 38/46 (2006.01)

Patent

CA 2129514

2129514 9317668 PCTABS00025 ACTH polymeric controlled release systems are described wherein the ACTH retains good biological activity and is released over an extended period of time following administration by injection. In the preferred embodiment, the ACTH polymeric microspheres are made using very cold temperatures to freeze the polymer-ACTH mixtures into polymeric microspheres with very high retention of biological activity and material. Sustained release of biologically active ACTH is achieved when the mircrospheres are tested in vitro), extending over a period of greater than one day to several months. Altered release can be achieved by inclusion of degradation modifiers, pore forming agents, and stabilizers of the ACTH.

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