Controlled synthesis of ziprasidone and compositions thereof

Details Controlled synthesis of ziprasidone and compositions thereof Controlled synthesis of ziprasidone and compositions thereof

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2475302

The subject invention provides a ziprasidone composition that comprises not greater than 1000 ppm des-chloro ziprasidone, preferably not greater than about 500 ppm des-chloro ziprasidone, and more preferably not greater than about 100 ppm des-chloro ziprasidone. Methods for synthesizing and using such ziprasidone compositions are also provided.

L'invention concerne une composition de ziprasidone comprenant de la deschloro-ziprasidone ne d~passant pas 1000 ppm, de pr~f~rence ne d~passant pas 500 ppm, et de pr~f~rence ne d~passant pas 100 ppm. L'invention concerne ~galement des proc~d~s de synth­se et d'utilisation desdites compositions de la ziprasidone.

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