Controlling availability or activity of proteins by use of...

Details Controlling availability or activity of proteins by use of... Controlling availability or activity of proteins by use of...

C - Chemistry, Metallurgy

07

K

C07K 14/72 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2323785

The invention relates to the field of proteins, more specifically to those proteins that are located on the surface of the cell. The invention amongst others provides an inhibitor or pharmaceutical composition that is capable of inhibiting down-regulation of a cell surface receptor. The invention provides a method to control or up-regulate hormone activity by using inhibitors or reagents that modify down-regulation of a protein. The invention further provides a method to control or up-regulate protein activity wherein ligand- induced receptor uptake and/or degradation by endocytosis of a receptor is inhibited, preferably by inhibiting the ubiquitin/proteasome system.

L'invention concerne le domaine des protéines, et plus particulièrement les protéines se trouvant à la surface de la cellule. L'invention concerne notamment un inhibiteur ou une composition pharmaceutique capable d'inhiber la régulation négative d'un récepteur de surface cellulaire. L'invention a trait à un procédé de commande ou de régulation positive de l'activité d'une hormone par utilisation d'inhibiteurs ou de réactifs qui modifient la régulation négative d'une protéine. L'invention concerne en outre un procédé de commande ou de régulation positive de l'activité d'une protéine, la capture d'un récepteur induite par un ligand et/ou la dégradation par endocytose du récepteur étant inhibée, de préférence par inhibition du système ubiquitine/protéasome.

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