Contulakin-g, analogs thereof and uses therefor

Details Contulakin-g, analogs thereof and uses therefor Contulakin-g, analogs thereof and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 9/00 (2006.01) C07K 14/435 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2347713

The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10- contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti- inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti- psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti- arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

La présente invention se rapporte à la contulakine-G (qui est un peptide glycosylé naturel), à une contulakine-G déglycosylée (appelée Thr¿10?-contulakine-G), et à leurs dérivés. L'invention se rapporte également à un clone d'ADNc encodant un précurseur de ce peptide mûr et à un peptide précurseur. Elle se rapporte en outre à l'utilisation de ce peptide comme analgésique, antipsychotique, ou comme agent thérapeutique contre l'hypotension, les troubles épileptiques, les troubles inflammatoires, les chocs, le thrombus, la maladie de Parkinson, les troubles gastrointestinaux, les états dépressifs, le dysfonctionnement cognitif, l'anxiété, la dyskinésie tardive, la toxicomanie, la crise de panique, la manie, le syndrome du côlon irritable, la diarrhée, l'ulcère, la tumeur gastro-intestinale, le syndrome de la Tourette, la chorée de Huntington, la fuite vasculaire, l'artériosclérose, les troubles vasculaires et la vasodilatation, ainsi que les troubles neurologiques, neuropharmacologiques ou neuropsychopharmacologiques.

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