Conversion of compactin to pravastatin by actinomadura

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 1/20 (2006.01) A61K 31/215 (2006.01) A61K 31/365 (2006.01) C12N 9/02 (2006.01) C12N 9/14 (2006.01) C12P 1/04 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2223122

A method for converting compactin to pravastatin is described. Compactin is provided and contacted with an agent derived from Actinomadura under conditions in which the agent converts compactin to pravastatin. Also described are an Actinomadura strain, an Actinomadura cell free extract, an Actinomadura hydroxylase, and a method for lowering cholesterol levels in mammals.

Cette invention concerne un procédé de transformation de compactine en pravastatine. La compactine est mise en contact avec un agent dérivé d'Actinomadura, dans des conditions permettant audit agent de transformer la compactine en pravastatine. Cette invention concerne également une souche d'Actinomadura, un extrait acellulaire d'Actinomadura, une hydroxylase d'Actinomadura, ainsi qu'un procédé permettant d'abaisser les taux de cholestérol chez les mammifères.

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