Conversion of liquid filled gelatin capsules into controlled...

Details Conversion of liquid filled gelatin capsules into controlled... Conversion of liquid filled gelatin capsules into controlled...

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/202 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2354472

A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, and expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.

L'invention concerne une forme posologique comprenant une capsule de gélatine formée par une paroi composite et contenant une formulation à base d'un principe actif liquide ; la paroi comprend une couche barrière formée sur la surface extérieure de la capsule de gélatine, une couche extensible formée au-dessus de la couche barrière, ainsi qu'une couche semi-perméable formée sur la couche extensible. Ces formes posologiques et les procédés de l'invention permettent de transformer des capsules de gélatine ordinaires contenant des formulations liquides en formes posologiques à libération régulée, dans le temps et l'environnement d'utilisation, desdits principes actifs.

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