Conversion of pyridinoline to deoxypyridinoline

Details Conversion of pyridinoline to deoxypyridinoline Conversion of pyridinoline to deoxypyridinoline

C - Chemistry, Metallurgy

07

D

C07D 213/65 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2236123

The present invention involves the synthetic conversion of pyridinoline (PYD) to deoxypyridinoline (DPD) via an intermediate ester which is subsequently cleaved. The transformation of PYD into a xanthate-type ester intermediate facilitates the subsequent removal of the substituted hydroxyl functionality thus providing the desired DPD. The method provides a new chemical pathway for the preparation of DPD, resulting in significantly increased yields as compared to traditional methods of product isolation.

L'invention concerne la conversion synthétique de la pyridinoline (PYD) en désoxypyridinoline (DPD) via un intermédiaire ester qui est ensuite coupé. La transformation de la PYD en un intermédiaire ester de type xanthate facilite l'élimination subséquente de la fonction hydroxyle substituée, fournissant ainsi la DPD souhaitée. La méthode fournit une nouvelle voie chimique pour la préparation de la DPD, se soldant par des rendements significativement accrus comparativement aux rendements des méthodes classiques pour isoler des produits.

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