Conversion of thebaine to morphine derivatives

Details Conversion of thebaine to morphine derivatives Conversion of thebaine to morphine derivatives

C - Chemistry, Metallurgy

07

D

C07D 489/02 (2006.01) C07D 489/04 (2006.01)

Patent

CA 2692429

The present invention provides methods for the conversion of the thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates fo the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence of a metal catalyst.

La présente invention porte sur des procédés de conversion de la thébaïne en un dérivé de morphine, tel que l'hydrocodone. L'invention porte également sur de nouveaux intermédiaires cétals pour la conversion. Un mode opératoire à un pot pour la conversion comprend le traitement de la thébaïne par un acide en présence d'un catalyseur métallique.

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