C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2473906
Disclosed is a composition comprising at least two synthetic, cooperative oligonucleotides, each comprising a region complementary to one of tandem, non- overlapping regions of a target single-stranded nucleic acid, and each further comprising a non-nucleotidic binding partner at a terminus of each of the oligonucleotides, such that the binding partners can interact with each other to form a stable complex. Also disclosed are dimeric structures, ternary complexes, pharmaceutical formulations, and methods utilizing the cooperative oligonucleotides of the invention.
L'invention concerne une composition comprenant au moins deux oligonucléotides coopératifs synthétiques, comprenant respectivement une région complémentaire à une des régions tandem non-chevauchantes d'un acide nucléique monocaténaire cible, et comprenant également respectivement un partenaire de liaison non-nucléotidique à une extrémité de chaque oligonucléotide, de telle façon que les partenaires de liaison puissent interagir les uns avec les autres pour former un complexe stable. L'invention concerne également des structures dimériques, des complexes centraux, des formulations pharmaceutiques et des procédés utilisant les oligonucléotides coopératifs de l'invention.
Agrawal Sudhir
Kandimalla Ekambar M.
Hybridon Inc.
Smart & Biggar
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