Cop1 molecules and uses thereof

Details Cop1 molecules and uses thereof Cop1 molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61P 35/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2584197

The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.

L'invention concerne des utilisations diagnostiques, pronostiques et thérapeutiques pour détecter une surexpression de COP1 dans une variété de cancers. Les méthodes et utilisations selon l'invention peuvent également consister à détecter l'expression de p53. L'invention concerne également des réactifs et des trousses destinés à être utilisés dans le criblage de composés tests qui interfèrent avec la liaison des COP1 avec des p53.

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