Copd biomarker signatures

Details Copd biomarker signatures Copd biomarker signatures

G - Physics

01

N

G01N 33/48 (2006.01) G06F 19/24 (2011.01) C40B 30/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2718251

The present invention relates to methods of detecting differentially expressed protein expression indicative of COPD in a test sample. The detection of circulating levels of proteins within an identified COPD biomarker signature can aid in COPD diagnosis and disease monitoring, as well as in the prediction of responses to therapeutics. Evaluation of the biomarker signatures disclosed, or a subset of biomarkers thereof, provides a level of discrimination not found with individual markers.

La présente invention concerne des procédés de détection dexpression de protéine exprimée de manière différentielle indicatrice de COPD dans un échantillon dessai. La détection des taux circulants de protéines ayant une signature de biomarqueur de COPD identifiée peut faciliter le diagnostic de COPD et la surveillance de la maladie, ainsi que la prédiction de réponses à des agents thérapeutiques. Lévaluation des signatures de biomarqueur décrites, ou d'un sous-ensemble de biomarqueurs de celles-ci, produit un niveau de discrimination non obtenu avec des marqueurs individuels.

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