Copolyesters useful in blood separation assemblies

C - Chemistry – Metallurgy – 08 – G

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233/1, 167/114,

C08G 63/48 (2006.01) B01L 3/14 (2006.01) C08G 63/20 (2006.01) C08K 3/00 (2006.01) C08L 67/08 (2006.01) G01N 33/48 (2006.01) G01N 33/49 (2006.01)

Patent

CA 1100684

ABSTRACT OF THE DISCLOSURE Copolyesters are provided which are derived from mixed dibasic acids and a branched-chain diol. The copolyesters comprise the reaction product of essentially stoichiometric amounts of (a) a saturated aliphatic dicarboxylic acid having 4 to 12 carbon atoms, (b) a polymeric fatty acid containing 75% by weight or more C36 dibasic acid, and (c) a branched- chain aliphatic dihydric alcohol having 3 to 8 carbon atoms, a mixture of the branched-chain dihydric alcohols, or a mixture containing at least 50% by weight the branched-chain aliphatic dihydric alcohols and a straight- chain aliphatic dihydric alcohol having 2 to 8 carbon atoms, the equivalents ratio of (a) to (b) ranging from 0.80:0.20 to 0.97:0.03, the copolyesters having an average molecular weight of 2,000 to 8,000, (a) 210°F. kinematic viscosity from 2,000 to 8,000 centistokes and (a) density in the range of 1.015 to 1.060 g/cm3. These copolyesters possess a unique balance of physical and chemical characteristics which permits their use in small amounts in blood separation tubes to provide an effective barrier between the light and heavy phases of the blood after centrifuging. A small but effective amount of the copolyester which is sufficient to form the barrier between the phases is inserted directly into the separation tube either before or after the blood sample is collected. During the untracentrifuga- tion they locate between. the serum or plasma phase and the heavier cellular phase, and when the centrifugation is terminated form a continuous integral barrier within the assembly substantially to prevent the phases from re- combining or mixing especially when decanting or pipetting the light phase.

303066

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