Copolymer coating for a hydrophobic membrane

B - Operations – Transporting – 01 – D

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B01D 61/00 (2006.01) A61M 1/36 (2006.01) B01D 63/00 (2006.01) B01D 63/02 (2006.01) B01D 67/00 (2006.01) C08J 7/04 (2006.01) C08L 81/06 (2006.01) C09D 171/02 (2006.01)

Patent

CA 2465260

A coating material and a method for coating a hydrophobic membrane with a copolymer that contains at least one hydrophilic segment and at least one hydrophilic segment, such as a PEO-PPO-PEO triblock copolymer, so that the surface of the membrane becomes hydrophilic. The hydrophilic coating helps repel biological molecules, thereby reducing the risk that these molecules will adsorb or deposit on the membrane surface. When the copolymers are modified with an active group, ligands can be immobilized on the copolymer through the active group so that specific molecules that will bind with the ligands cna be targeted for immobilization on the copolymer coating, thereby improving the efficiency of the removal of specific targets.

L'invention concerne un matériau de revêtement et un procédé de revêtement d'une membrane hydrophobe avec un copolymère qui contient au moins un segment hydrophobe et au moins un segment hydrophile, tel qu'un copolymère triplement séquencé PEO-PPO-PEO, afin que la surface de la membrane devienne hydrophile. Le revêtement hydrophile aide à repousser des molécules biologiques, ce qui permet de diminuer le risque que ces molécules soient absorbées ou déposées sur la surface de la membrane. Lorsque les copolymères sont modifiés avec un groupe actif, des ligands peuvent être immobilisés sur les copolymères à travers le groupe actif de façon que des molécules spécifiques qui se lient avec les ligands puissent être ciblées pour immobilisation sur le revêtement copolymère, ce qui permet d'améliorer l'efficacité du retrait de cibles spécifiques.

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