A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 9/51 (2006.01) A61K 31/335 (2006.01) A61K 38/13 (2006.01)
Patent
CA 2231886
A water-soluble micelle-type drug composition carrying paclitaxel, cyclosporin A or adriamycin is found to be particularly effective when it is composed of a water-soluble amphiphilic block copolymer micelle having a hydrophilic poly(alkylene oxide) component and a hydrophobic biodegradable component, and the drug physically trapped in the micelle; wherein the block copolymer is not cross-linked by a cross- linking agent and has a molecular weight of 10,000 daltons or less; the hydrophilic component is 70 wt% or less based on the total weight of the block copolymer; and the hydrophobic component is a biodegradable polymer selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(lactic-co-glycolic acid), poly(.epsilon.-caprolactone) and a mixture thereof.
L'invention concerne un système d'administration d'un médicament micellaire comprenant un copolymère séquencé constitué d'une séquence hydrophobe et d'une séquence hydrophile. La séquence hydrophobe est un polymère hydrophobe biodégradable choisi dans un groupe constitué de polylactide, polyglycolide, poly(lactide glycolide), polycaprolactone et des dérivés de ces substances; le polymère hydrophile est un poly(alkylène oxyde). Un utilisateur peut incorporer facilement un médicament hydrophobe à la micelle en utilisant un procédé simple pour obtenir une composition de médicament thérapeutiquement efficace.
Chang Eun Ok
Kim Sung Chul
Pai Chaul Min
Song In Suk
Cassan Maclean
Sam Yang Co. Ltd.
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