Copolymers and their use as contrast agents in magnetic...

Details Copolymers and their use as contrast agents in magnetic... Copolymers and their use as contrast agents in magnetic...

C - Chemistry, Metallurgy

08

G

C08G 63/68 (2006.01) A61B 19/00 (2006.01) A61K 49/00 (2006.01) A61K 49/12 (2006.01) A61K 51/06 (2006.01) C07K 16/18 (2006.01) C07K 17/08 (2006.01) C08B 37/02 (2006.01) C08G 69/40 (2006.01) C08G 69/42 (2006.01) C08G 69/48 (2006.01) C08G 75/26 (2006.01) C08G 79/00 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2116357

2116357 9306148 PCTABS00021 Compounds used as contrast agents in MRI are described. The compounds comprise a copolymer comprising at least two of a first monomer of the formula: X1-(CHR2CHR2-Y)n-(CHR2)m-CHR2CHR2-X2, wherein X and X2 are, independently, OH, NH2, NHR1, COOH, COOR1, SH, or Z, Y is O, NH, NR1, S, or CO, n is 0-10,000, m is 0 or 1, each Z is C20 substituted alkyl or cycloalkyl, and each R2 is, independently, H or OH, and at least one of a second monomer which is a polynitrilo chelating agent having at least two COOH, COOR1, or COZ groups, the first and second monomers bound to one another from a copolymer through an ester, amide, or carboxylic thioester linkage of at least one of OH, NH2, NHR1, COOH, COOR1, SH or Z groups of the first monomer, and at least one of the COOH, COOR1, or COZ groups of the second monomer. A third monomer which is a targeting agent or ligand having an OH, NH2, NHR1, COOH, COOR1, SH or COZ is optionally included. The third monomer forms an ester, amide, or carboxylic thioester linkage with the others. A paramagnetic ion chelated to the chelating agent may be added.

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