C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 69/10 (2006.01) A61K 38/16 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 37/06 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C08G 69/06 (2006.01) C08G 69/48 (2006.01) C07K 1/00 (2006.01)
Patent
CA 2614171
Random three- and four-amino acid copolymers having lengths of 14-,35- and 50- amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85- 99 or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed EAE induced in susceptible SJL/J (H-2?s~) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151. YFAK 50-mer having a molar ratio of about y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone$m(3). YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2?s~) mice with the encephalitogenic epitope PLP 139-151. Copolymers YFK, VYAK and tryptophan- containing VWAK were efficacious in alleviating severity and duration of symptoms of EAE induced by MBP 85-99, in a humanized mouse model expressing genes for both an HLA-DR-2 linked to multiple sclerosis (MS) in humans and for a T cell receptor from an MS patient.
Fridkis-Hareli Masha
Strominger Jack L.
President And Fellows Of Harvard College
Smart & Biggar
LandOfFree
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