Copolymers for transporting nucleic acids in the cell

Details Copolymers for transporting nucleic acids in the cell Copolymers for transporting nucleic acids in the cell

C - Chemistry, Metallurgy

08

G

C08G 65/329 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C08G 65/333 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2377211

The invention relates to copolymers that are obtained from an amphiphilic polymer, preferably polyethylene glycol, and a charged effector molecule, especially a peptide or peptide derivative. The invention also relates to nucleic acid complexes for use as non-viral vectors in gene therapy in which nucleic acid is condensed with a polycation and which contain the charged copolymer bound to their surface.

La présente invention concerne des copolymères obtenus à partir d'un polymère amphiphile, de préférence du polyéthylène glycol, et d'une molécule effectrice chargée, en particulier un peptide ou dérivé peptidique. Elle concerne également des complexes d'acide nucléique dans lesquels l'acide nucléique est condensé avec un polycation et qui contiennent le polymère chargé lié à leur surface, utilisés en tant que vecteurs non viraux pour la thérapie génique.

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