Copolyvidone-containing preparation

Details Copolyvidone-containing preparation Copolyvidone-containing preparation

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/28 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)

Patent

CA 2650698

Disclosed is a stabilized preparation which comprises a drug unstable in a polyethylene glycol-containing preparation and a coating agent comprising a copolyvidone instead of polyethylene glycol with which the drug is coated, wherein the unstable drug in the polyethylene glycol-containing preparation is a compound represented by the formula: (see formula II) wherein: Ar represents an optionally substituted aromatic group, X' represents a divalent C1-6 aliphatic hydrocarbon group which optionally have 1 or 2 divalent groups selected from the group consisting of -O-, -S-, -CO-, -SO-, -SO2- and -COO-, Y' represents a divalent C1-6 aliphatic hydrocarbon group, R' and R'' are the same or different and each represents a hydrogen atom or an optionally substituted C1-6 alkyl, ring A' represents a benzene ring which may be further substituted, and ring B' represents a 4- or 8- membered ring which may be further substituted, or a pharmaceutically acceptable salt thereof.

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