Copper agonist that binds on the copper binding site of app...

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/30 (2006.01) A61K 33/06 (2006.01) A61K 33/24 (2006.01) A61K 33/34 (2006.01) A61K 38/16 (2006.01) A61P 25/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2371934

The invention relates to copper agonists that bind on the copper binding site of APP and/or exert an inhibiting effect on the release of the amyloid A.beta. peptide participating in the emergence of Alzheimer's disease. The invention also relates to the drugs containing said copper agonists or to the utilization of said copper agonists for the preparation of a drug for the prevention and/or treatment of Alzheimer's disease. The invention further relates to a method for identifying copper agonists having the desired effect described in the invention.

Cette invention concerne des agonistes du cuivre qui se lient au site de fixation du cuivre de l'APP et/ou exercent une action d'inhibition sur la libération du peptide bêta-amyloïde qui contribue à l'apparition de la maladie d'Alzheimer. Cette invention concerne également des produits pharmaceutiques contenant ces agonistes du cuivre ou l'utilisation de ces agonistes du cuivre pour fabriquer des produits pharmaceutiques de prévention et/ou de traitement de la maladie d'Alzheimer et enfin un procédé d'identification des agonistes du cuivre ayant l'effet désiré selon l'invention.

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