C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/04 (2006.01) C07D 249/06 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2487424
A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted ~1,2,3~-triazoles.
Selon cette invention, un procédé de ligation chimique à haute affinité catalysé par un métal est utilisé pour lier des azides et des acétyléniques vrais pour donner des triazoles. Dans de nombreux cas, la séquence de réactions effectue une ligation de manière régio-spécifique des azides et des acétyléniques vrais pour donner uniquement des Ý1,2,3¨-triazoles 1,4-disubstitués.
Fokin Valery
Green Luke
Himo Fahmi
Rostovsev Vsevolod
Sharpless K. Barry
The Scripps Research Institute
Torys Llp
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