A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 31/355 (2006.01) A61K 33/24 (2006.01) A61K 33/34 (2006.01) A61K 38/20 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07K 14/715 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2458622
The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods for preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
La présente invention concerne une découverte, selon laquelle l'export non traditionnel de certaines cytokines pro-inflammatoires exemptes d'une séquence de signaux provenant d'une cellule peut être inhibé par la chélation du cuivre et/ou par l'administration à la cellule d'une forme tronquée de S100A13 exempte de la portion de résidu de base. En outre, la chélation du cuivre inhibe, <i>inter alia</i>, la formation d'une néointima, l'infiltration de macrophages et une inflammation liée, la prolifération cellulaire, la sécrétion d'une matrice extracellulaire, l'épaississement intimal, l'angiogénèse de Rouget, la resténose, et similaire, associés à une lésion vasculaire. Cette invention a également trait à de nouvelles méthodes de prévention et de traitement et d'identification de nouveaux composés utilisés en tant qu'agents thérapeutiques destinés à de tels troubles.
Bagala Cinzia
Bellum Stephen
Maciag Thomas
Mandinov Lazar
Mandinova Anna
Gowling Lafleur Henderson Llp
Maine Medical Center Research Institute
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