Coralyne analogs as topoisomerase inhibitors

Details Coralyne analogs as topoisomerase inhibitors Coralyne analogs as topoisomerase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 455/03 (2006.01) A61K 31/47 (2006.01) C07D 217/16 (2006.01) C07D 217/24 (2006.01) C07D 405/04 (2006.01) C07D 491/04 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2241551

The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as topoisomerase inhibitors. The invention further provides coralyne and nitidine derivatives which are topoisomerase I- targeted therapeutics effective against camptothecin resistant cancer cells, and are especially effective against CNS tumors.

L'invention concerne des dérivés d'alcaloïde de protoberbérine utiles en tant qu'agents anti-cancer, ainsi que leurs procédés d'utilisation. Elle concerne également des dérivés de protoberbérine utiles en tant qu'inhibiteurs de topoisomérase. Elle concerne encore des dérivés de coralyne et de nitidine qui sont des agents thérapeutiques dirigés contre la topoisomérase I et efficaces contre les cellules cancéreuses résistant à la camptothécine, ainsi que, particulièrement, contre les tumeurs du système nerveux central.

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