Core 2 glcnac-t inhibitors

Details Core 2 glcnac-t inhibitors Core 2 glcnac-t inhibitors

A - Human Necessities

61

K

A61K 31/702 (2006.01) C07H 3/00 (2006.01)

Patent

CA 2549118

The present invention relates to the use of known and novel compounds as inhibitors of UDP-G1cNAc:Gal.beta.1,3GalNAc-R (GlcNAc to GalNAc) .beta.1,6-N- acetylglucosaminyl transferase (core 2 .beta.1,6 N-acetylaminotransferase, core 2 GlcNAc-T -EC 2.4.1.102). Such inhibitors have applications in therapy for diseases associated with raised activity of core 2 GlcNAc-T, in particular inflammatory diseases, atherosclerosis, diabetic cardiomyopathy, cancers - including treatment or prevention of metastasis - or diabetic retinopathy.

La présente invention se rapporte à l'utilisation de composés connus et de nouveaux composés en tant qu'inhibiteurs de la UDP-GlcNAc:Gal.beta.1,3GalNAc-R (GlcNAc à GalNAc) .beta.1,6-N- acétylglucosaminyl-transférase (.beta.1,6 N-acétylaminotransférase à noyau 2, GlcNAc-T -EC 2.4.1.102 à noyau 2). Ces inhibiteurs peuvent être utilisés pour le traitement de maladies associées à une activité accrue de la GlcNAc-T à noyau 2, en particulier des maladies inflammatoires, de l'athérosclérose, de la myocardiopathie diabétique, des cancers -notamment traitement ou prévention des métastases- ou de la rétinopathie diabétique.

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